The Week 7 NFL schedule is arguably the most loaded of the year, highlighted by a Super Bowl rematch of Chiefs vs. 49ers at 4:25 p.m. ET on Sunday. Kansas City is a two-point road underdog, per the latest Week 7 NFL odds, after also being a 1.5-point underdog in “The Big Game” in February. The undercard to 49ers vs. Chiefs is Vikings vs. Lions (+1.5, 50.5) at 1 p.m. ET, which could be an NFC Championship Game preview. Seven NFL spreads on Sunday are lined within a field goal.
That’s not all football fans can look forward to on Sunday, as other top matchups include Packers vs. Texans (+3, 48), Seahawks vs. Falcons (-3, 51.5), and Giants vs. Eagles (-3, 41.5). As part of a Monday Night Football doubleheader, the Ravens will visit the Buccaneers, with Baltimore favored by 3.5 points according to the Week 7 NFL spreads and an over-under of 49.5, up five from the opener. All of the Week 7 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 7 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2024 NFL season on an incredible 11-3 hot streak on top-rated NFL picks this year. Longer term, it is on a 192-132 roll on top-rated NFL picks that dates back to the 2017 season and a 46-24 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up at sportsbooks and betting apps.
Now, it has turned its attention to the latest Week 7 NFL odds and NFL betting lines and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 7 NFL predictions
We can tell you one of the model’s strongest Week 7 NFL picks is that the Vikings (-1.5, 50.5) cover the spread against the Lions. Minnesota wins by nearly a touchdown, per the model, as it has a pair of clear advantages in this matchup. The Vikings will be well-rested, coming off a bye, while Detroit won versus Dallas but lost arguably its best played in defensive end Aidan Hutchinson. He leads the NFL with 7.5 sacks but suffered a broken leg against the Cowboys, severely hampering Detroit’s pass rush.
Even with him, the Lions were just middle-of-the-pack in terms of pressure percentage and sacks, ranking 13th in each. He’s accounted for half of the team’s 15 sacks, so his absence will allow Sam Darnold all day to find Justin Jefferson. Darnold already ranks fourth in the league in passing touchdowns and sixth in passer rating, and the SportsLine model projects he’ll have nearly 300 passing yards and two touchdowns on Sunday. That will enable the Vikings to cover over 60% of the time. See which other teams to pick here.
Another one of its Week 7 NFL betting predictions: the Chargers (-1.5, 44) cover on the road against the Cardinals as part of a Monday Night Football doubleheader. After being run-heavy through their first four games, the Chargers showed a more balanced offensive attack after their bye. Justin Herbert had 237 passing yards in a win over Denver after averaging 144.5 yards over his first four games. The running backs were still major factors as J.K. Dobbins and Kimani Vidal combined for 153 scrimmage yards and two touchdowns.
As for the Cardinals, they were blown out by three touchdowns to the Packers, and Arizona has a -48 point differential over its last three games. The Cards committed three turnovers in the defeat, and that makes it hard to win, especially when you have the last-ranked third-down defense in the league. Kyler Murray has one or fewer touchdown passes in 11 of his last 14 games, and that simply won’t provide enough offense to topple a rejuvenated Chargers attack. Los Angeles (-1.5) covers well over 60% of the time, with the model also saying the Over hits in nearly 60% of simulations. See which other teams to pick here.
How to make Week 7 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 7 NFL schedule and just revealed three coveted A-rated picks, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which three must-see teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 7 NFL betting odds, lines, spreads
Get Week 7 NFL picks at SportsLine
Sunday, Oct. 20
Seahawks at Falcons (-3, 51.5)
Bengals at Browns (+5.5, 41.5)
Texans at Packers (-3, 48)
Lions at Vikings (-1.5, 50.5)
Eagles at Giants (+3, 41.5)
Panthers at Commanders (-9.5, 51.5)
Chiefs at 49ers (-2, 47)
Monday, Oct. 21
Ravens at Buccaneers (+3.5, 49.5)
Chargers at Cardinals (+1.5, 44)